Selected Publications:


Faustino J, Chip S, Derugin N, Jullienne A, HamerM, HaddadE, Butovsky O, ObenausA. and Vexler ZS. “CX3CR1-CCR2-dependent monocyte-microglial signaling modulates neurovascular leakage and acute injury in a mouse model of childhood stroke”. JCBFM, 2019: 271678X18817663. PMID: 30628839


Ardalan M, Chumak T, Vexler ZS, Mallard C. “Sex-Dependent Effects of Perinatal Inflammation on the Brain: Implication for
Neuro-Psychiatric Disorders”.Int J Mol Sci. 2019, 20, 2270; doi:10.3390/ijms20092270


Mallard C, Tremblay M-E, Vexler Vexler ZS “Microglia and neonatal brain injury”. Neuroscience, 2018. doi:


Mallard C, Ek CJ, Vexler ZS. The myth of the immature barrier systems in the developing brain: role in perinatal brain injury. J. Physiology. 2018 March 12. PubMed PMID: 29528501. PMCID: PMC6265562


Vexler ZS, Mallard C, Hagberg H. Positive and negative conditioning in the neonatal brain. Conditioning Medicine. 2018. 1(6):279-293. NIHMS 997619.


Chip S, Fernandez Lopez D, Faustino J, Li F, Derugin N, Vexler ZS. “Genetic deletion of galectin-3 enhances neuroinflammation, affects microglial activation and contributes to sub-chronic injury in experimental neonatal focal stroke”. Brain Behavior & Immunity, 2017 Feb;60:270-281.PMID: 28579520


Lalancette-Hébert M, Faustino J, Thammisetty SS, Chip S, Vexler ZS*, Kriz J*. “Live imaging of the innate immune response in neonates reveals differential TLR2 dependent activation patterns in sterile inflammation and infection”. Brain Behav Immun. 2017 Oct;65:312-327. PMID: 28579520. * - co-senior authors.


van Velthoven CT, Dzietko M, Wendland M, Derugin N, Faustino J, Heijnen C, Ferriero D, Vexler ZS. “Mesenchymal stem cells attenuate MRI-identifiable injury, protect white matter and improve long-term functional outcomes after neonatal focal stroke in rats”. J.Neurosci Res, 2016 May;95(5):1225-1236. PMID: 27781299.


Fernandez Lopez D, Faustino J, Klibanov A, Derugin N, Blanchard E, Simon F, Leib S, Vexler ZS. Microglial cells prevent hemorrhagic transformation after neonatal arterial stroke. J. Neurosci. 2016, Mar 9;36(10):2881-93. PMID: 26961944


Hagberg H, Mallard C, Ferriero DM, Vannucci S, Levison S, Vexler ZS and Gressens P. “Role of inflammation in perinatal brain injury”. Nature Review Neurology 2015, Apr;11(4):192-208. doi: 10.1038/nrneurol.2015.13. Epub 2015 Feb 17. Review. PMID: 25686754.


Li F, Faustino J, Woo M, Derugin N, Vexler ZS. Lack of the scavenger receptor cd36 alters microglial phenotypes after neonatal stroke. J Neurochem. 2015;Jul 30. doi: 10.1111/jnc.13239. PMID: 26223273


Mallard C and Vexler ZS. “Modeling Ischemia in the Immature Brain: How Translational Are Animal Models?” Stroke, 2015. 46:3006-11. doi: 10.1161/STROKEAHA.115.007776. Epub 2015 Aug 13. PMID: 26272384


SohetF, LinC, MunjiR, LeeS, RuderischN, SoungA, ArnoldT, DeruginN, Vexler ZS, YenF and Daneman R “LSR/Angulin-1 is a tricellular tight junction protein involved in blood-brain barrier formation” J Cell Biol. Mar 16;208(6):703-11. doi: 10.1083/jcb.201410131. Epub 2015 Mar 9. PMID: 25753034. PMCID: PMC4362448


Fernández-López D, Natarajan N, Ashwal S, and Vexler ZS. “Mechanisms of Perinatal Arterial Ischemic Stroke”, JCBFM, 2014, 34(6):921-923. PMID: 24667913


van Velthoven CT, Sheldon RA, Kavelaars A, Derugin N, Vexler ZS, Willemen HL, Maas M, Heijnen CJ, Ferriero DM. “Mesenchymal stem cell transplantation attenuates brain injury after neonatal stroke”. Stroke. 2013, 44(5):1426-32. PMID: 23539530


Fernández-López D, Faustino J, Derugin N, Vexler ZS. “Acute and chronic vascular responses to experimental focal arterial stroke in the neonate rat”. Translational Stroke Res, 2013, 4 (2):179-188. PMCID: PMC3665524


Fernandez-Lopez D, Faustino J, Derugin N, Wendland M, Lizasoain I, Moro A, and Vexler ZS. “Reduced infarct size and accumulation of microglia in rats treated with WIN 55,212-2 after neonatal stroke”. Neurosci, 2012, 207:307-15. Epub 2012 Jan 12. PMID: 22285309


Woo MS, Wang X, MD, Faustino J, Derugin N, Wendland M, Zhou P, Iadecola C,and Vexler ZS. “Genetic deletion of CD36 enhances injury after acute neonatal stroke“, Ann Neurol, 2012, 72:961-970. PMID: 23280844


Fernández-López D, Faustino J, Daneman R, Zhou L, Lee SY, Derugin N, Wendland MF, Vexler ZS. “Blood-brain barrier permeability is increased after acute adult stroke but not neonatal stroke”. J Neurosci. 2012 Jul 11;32(28):9588-600. PMID: 22787045


Faustino J, Wang X, Jonhson C, Klibanov A, Derugin N, Wendland M, Vexler ZS. Microglial cells contribute to endogenous brain defenses after acute neonatal focal stroke. J Neurosci. 2011 31(36):12992-3001. PMID: 22285309 Cited in the “Discoveries in Neuroscience” section, Ann Neurol, 2011, 70:A9


Dzietko M, Wendland M, Derugin N, Ferriero DM, Vexler ZS. "MRI as a Translational Tool for the Study of Neonatal Stroke" J Child Neurol, 2011, 26(9):1145-53. PMID: 21670390


Biran V, Heine V, Verney C, Vexler ZS, Rowitch D, Ferriero, DM “Cerebellar abnormalities following hypoxia alone compared to hypoxic-ischemic forebrain injury in the developing rat brain. NBD, 2011 41:138-146. PMID: 20843479


Shimotake J, DeruginN, WendlandM, Vexler ZS* and Ferriero DM*. “Vascular Endothelial Growth Factor Receptor2 inhibition promotes cell death and limits endothelial cell proliferation in a neonatal rodent model of stroke”. Stroke, 2010, 41:343-349. * - co-senior authors. PMID: 20101028


Vexler ZS and Yenary M “Does inflammation after stroke affect the developing brain differently than adult brain?”. Dev Neurosci. 2009;31:378-393. PMID: 19672067


Wendland M, Faustino J, West T, Holtzman D, and Vexler ZS “Early diffusion-weighted MRI as predictor of caspase-3 activation following hypoxia-ischemia in neonatal rodents”. Stroke, 2008, 39:1862-1868. PMID: 18420950


Gonzalez, P. McQuillen, D. Mu, Y. Chang, Wendland M, Vexler ZS, Ferriero DM, “Erythropoietin enhances long-term neuroprotection and neurogenesis in neonatal stroke”. Dev Neurosci 2007, 29: 321-330. PMID: 17762200


Denker, Ji S, Lee SY, Dingman A., Derugin N, Wendland MF, Vexler ZS. “Macrophages are comprised of resident brain microglia not infiltrating peripheral monocytes acutely after neonatal stroke”. J Neurochem. 2007, 100: 893-904. PMID: 17212701


Dingman A, Lee SY, Derugin N, Wendland MF, Vexler ZS. “Aminoguanidine inhibits caspase-3 and calpain activation without affecting microglial activation following neonatal transient ischemia” J. Neurochem. 2006, 96: 1467–1479. PMID: 16464234


Derugin N, Dingman A, Wendland MF, Fox C, Vexler ZS. “Magnetic resonance imaging as a surrogate measure for histological sub-chronic endpoint in a neonatal rat stroke model”. Brain Res. 2005;1066: 49-56.


Fox C, Dingman A, Derugin N, Wendland MF, Manabat C, Ji S, Ferriero DM, Vexler ZS, “Minocycline confers early but transient protection in the immature brain following focal cerebral ischemic-reperfusion” JCBFM, 2005, 25: 1138-1149. PMID: 15874975


Manabat C, Han H, Wendland MF, Derugin N, Holtzman D, Ferriero DM, Vexler ZS. “Reperfusion differentially induces caspase-3 activation in ischemic core and penumbra after focal ischemia in immature brain”. Stroke, 2003, 34(1):207-213.


Mu DZ, X.N. Jiagn, Sheldon RA, C.K. Fox, S. Hamrick, Vexler ZS, Ferriero DM, “Regulation of hypoxia-inducible factor-1a and induction of vascular endothelial growth factor in a rat neonatal stroke model” Neurobiol. Dis., 2003, 14: 524-534. PMID: 16023639


Parent J, Vexler ZS, Derugin N, Gong C, Ferriero FM. ‘Focal Cerebral Ischemia Increases Adult Rat Forebrain Subventricular Zone Neuroblast Proliferation and Induces Neostriatal Neurogenesis’. Annals of Neurology, 2002, 52(6):802-813.


Derugin N, Ferriero DM and Vexler ZS, "Neonatal reversible focal cerebral ischemia: a new model". Neurosci. Res., 1998, 32:349-353.